DNA Damaging Agents
DNA writes the code which makes our cells, and makes you you. Unfortunately, DNA is as fundamental to cancer as it is to life. DNA damaging agents (DDAs) can be used to treat prostate cancer. Examples include existing treatments such as radiotherapy and most forms of chemotherapy as well as newer therapies like PARP inhibitors. They work by damaging DNA leading to the death of cancer cells.
Unfortunately, DDAs do not work for everyone and at the moment, it is not clear why some patients benefit from these treatments, while others do not. This can make it difficult to know the best way to treat an individual’s prostate cancer. Different cancers have unique features which may make them particularly suitable or particularly unsuitable for a certain type of treatment. It may be possible to find patterns in the DNA of tumours that can be used to predict which treatment will work best for the individual patient.