The Problem with Hormone Therapy
Unfortunately, for many prostate cancer patients, hormone therapy will eventually stop working.
Prostate cancers can develop resistance and will continue to grow and spread despite ongoing treatment. One reason for this is the androgen receptor itself changes, so that the part that normally attaches to the hormone is missing. There’s nowhere for the hormone therapy to stick to, and so the receptor is always switched on. Therefore, messages telling the cancer cell to grow, and divide continue to be sent. These forms of the androgen receptor are known as androgen receptor variants (ARVs).
There are currently no treatments that can overcome this resistance which makes it an important target for research.