The Mystery of PTEN
PTEN is an 'off switch' which doesn’t work properly in almost all advanced prostate cancers.
Despite this, we still don’t know the best way to target these cancers due to the complicated network of genetic ‘switches’. Cancer is a very complex disease and PTEN is not working alone.
Very little is known about the other changes that happen at the same time that PTEN is lost. Science is currently identifying genetic changes much more quickly than we can work out what these genetic changes do. Therefore, we don’t understand how PTEN loss and other changes or ‘switches’ inside the cell work together to drive the growth and spread of prostate cancer.