Our Research The Spread of Prostate Cancer The Scientists Dr Magali Williamson Dr Boris Shorning Professor Anne Ridley Dr Matthew Smalley The Objective This research is identifying the genetic changes that allow prostate cancer cells to spread so that therapy can be developed to prevent spread and kill the cancer cells that have spread. About the research There are enormous gaps in our understanding of how and why cancer cells spread. Prostate cancer cells can develop the ability to migrate out of their normal environment and then invade blood vessels and get carried around the body in the blood to grow at distant sites. Our scientists argued that if we could understand how prostate cancer cells acquire the ability to spread, then it might be possible to halt the process or target and kill the cancer cells that had spread. Dr Magali Williamson, working in the PCRC laboratory, set out to identify changes that allow prostate cancer cells to spread. She started by looking at proteins that help cells move. She thought that mutations (changes in the structure) of one of these proteins might be crucial. Dr Williamson selected a small number of proteins to study, concentrating on Plexins. Through studying prostate cancer tissue samples, she discovered that one of these proteins, called Plexin B1, is overexpressed and mutated in the vast majority of prostate cancer cases. These findings suggested that the mutations are one of the changes enabling prostate cancer cells to spread. Her discovery was published in the prestigious scientific journal, Proceedings of the National Academy of Sciences. In order to prove that the mutations help prostate cancer cells to spread, Dr Williamson has worked with our colleagues Dr Matthew Smalley and Dr Boris Shorning at Cardiff University. In animal models, they have confirmed that an overexpression of Plexin B1 increased the spread of prostate cancer. Dr Williamson has continued to study the mechanism by which the mutations in Plexin B1 help the cancer cells migrate. This work has identified a number of potential therapeutic targets in prostate cancer that might be used to attack the cancer cells. She is currently evaluating different antibodies which aim to stop Plexin B1 causing the spread of prostate cancer. Significance While prostate cancer is retained within the prostate, it can be cured with radiotherapy or surgery. It is the spread of the disease that makes the difference between cure and failure. Dr Williamson's work is exciting because the new antibodies being developed could halt the deadly spread of prostate cancer.