Project No. 05

PTEN: Finding the off switch

Investigating the genetics behind the growth and spread of prostate cancer

S c r o l l   R i g h t

What could this achieve?

This project aims to understand the underlying genetics driving the growth and spread of prostate cancer. This understanding could eventually be used to identify new ways to treat prostate cancer.

How?

Dr de la Rosa has created a new genetic tool which can alter many genes at once. He will explore what happens when the tumour suppressor gene PTEN is lost, and how various genetic changes inside the cell work together to drive prostate cancer.

The Future- what’s next?

Dr de la Rosa will use his genetic tool to generate hundreds of loss-of-function mutations in the mouse prostate and they hope to eventually reveal the genetic weaknesses of prostate cancer cells to identify new therapeutic targets.

What could this achieve?

This project aims to understand the underlying genetics driving the growth and spread of prostate cancer. This understanding could eventually be used to identify new ways to treat prostate cancer.

How?

Dr de la Rosa has created a new genetic tool which can alter many genes at once. He will explore what happens when the tumour suppressor gene PTEN is lost, and how various genetic changes inside the cell work together to drive prostate cancer.

The Future- what’s next?

Dr de la Rosa will use his genetic tool to generate hundreds of loss-of-function mutations in the mouse prostate and they hope to eventually reveal the genetic weaknesses of prostate cancer cells to identify new therapeutic targets.

Project Start

November 2019

Research Facility

University of Cambridge

Budget

£100,000/year

End

November 2020

Dr Jorge de la Rosa

Team Leader

Jorge de la Rosa studied biology and completed a PhD in his native Spain. Jorge’s PhD research revealed that a protein causing premature ageing, called prelamin A, can also protect from cancer, settling decades of debate in the research community.

Following on from his PhD, Jorge was awarded a prestigious FEBS Long-Term Fellowship, and decided to move to Cambridge in 2014 to pursue his scientific career under the supervision of Professor Allan Bradley. His postdoctoral studies focused on using complex genetic models and screening approaches to gain insights into the genetic and non-genetic mechanisms driving prostate cancer. Early this year Jorge was appointed Associate Principal Investigator at the University of Cambridge, hosted by Professor Bradley in his laboratory.

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